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Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.

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第一作者： Chun-Qing,Song

第一单位： RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts.

作者： Chun-Qing,Song ^[1] ; Yingxiang,Li ^[2] ; Haiwei,Mou ^[1] ; Jill,Moore ^[3] ; Angela,Park ^[1] ; Yotsawat,Pomyen ^[4] ; Soren,Hough ^[1] ; Zachary,Kennedy ^[1] ; Andrew,Fischer ^[5] ; Hao,Yin ^[6] ; Daniel G,Anderson ^[7] ; Darryl,Conte ^[1] ; Lars,Zender ^[8] ; Xin Wei,Wang ^[4] ; Snorri,Thorgeirsson ^[4] ; Zhiping,Weng ^[9] ; Wen,Xue ^[10]

作者单位： RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts. ^[1] Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts; Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, China. ^[2] Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts. ^[3] Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. ^[4] Department of Pathology, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts. ^[5] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. ^[6] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts; Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts. ^[7] Department of Internal Medicine VIII, University Department of Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Physiology I, Institute of Physiology, Eberhard Karls University, Tübingen, Germany. ^[8] Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts; Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, China. Electronic address: Zhiping.Weng@umassmed.edu. ^[9] RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts; Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address: Wen.Xue@umassmed.edu. ^[10]

关键词 CRISPR Screen Liver Cancer Mouse Model Tumor Suppressor Genes