Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

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第一作者： Fernanda S,Neves

第一单位： School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil.

作者： Fernanda S,Neves ^[1] ; Patrícia T,Marques ^[1] ; Fernanda,Barros-Aragão ^[2] ; José Bruno,Nunes ^[3] ; Aline M,Venancio ^[4] ; Danielle,Cozachenco ^[1] ; Rudimar L,Frozza ^[5] ; Giselle F,Passos ^[1] ; Robson,Costa ^[1] ; Jade,de Oliveira ^[4] ; Daiane F,Engel ^[4] ; Andreza F,De Bem ^[4] ; Claudia F,Benjamim ^[3] ; Fernanda G,De Felice ^[6] ; Sergio T,Ferreira ^[7] ; Julia R,Clarke ^[8] ; Claudia P,Figueiredo ^[9]

作者单位： School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil. ^[1] School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil.;Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil. ^[2] Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil. ^[3] Center for Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil. ^[4] Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil. ^[5] Centre for Neuroscience Studies, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. ^[6] Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil.;Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil. ^[7] School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil. juclarke@gmail.com. ^[8] School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil. claufig@gmail.com. ^[9]

关键词 Cognitive impairment Glycogen synthase kinase 3 β (GSK3β)Insulin receptor substrate-1 (IRS-1) inhibition Late cognitive impairment Liraglutide Sepsis survivors TDZD-8