首页> Journal of medicinal chemistry> Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

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第一作者： Mark D,Chappell

第一单位： Discovery Chemistry Synthesis Group, Centro de Investigación Lilly S.A. Avda. de la Industria , 30 Alcobendas, Madrid 28108, Spain.

作者： Mark D,Chappell ^[1] ; Renhua,Li ^[1] ; Stephon C,Smith ^[1] ; Bruce A,Dressman ^[1] ; Eric G,Tromiczak ^[1] ; Allie E,Tripp ^[1] ; Maria-Jesus,Blanco ^[2] ; Tatiana,Vetman ^[2] ; Steven J,Quimby ^[2] ; James,Matt ^[2] ; Thomas C,Britton ^[2] ; Adam M,Fivush ^[2] ; Jeffrey M,Schkeryantz ^[2] ; Daniel,Mayhugh ^[2] ; Jon A,Erickson ^[2] ; Mark G,Bures ^[3] ; Carlos,Jaramillo ^[3] ; Mercedes,Carpintero ^[4] ; José Eugenio de,Diego ^[4] ; Mario,Barberis ; Susana,Garcia-Cerrada ; José F,Soriano ; Stephen,Antonysamy ; Shane,Atwell ; Iain,MacEwan ; Bradley,Condon ; Christine,Sougias ; Jing,Wang ; Aiping,Zhang ; Kris,Conners ; Chris,Groshong ; Stephen R,Wasserman ; John W,Koss ; Jeffrey M,Witkin ; Xia,Li ; Carl,Overshiner ; Keith A,Wafford ; Wesley,Seidel ; Xu-Shan,Wang ; Beverly A,Heinz ; Steven,Swanson ; John T,Catlow ; David W,Bedwell ; James A,Monn ; Charles H,Mitch ; Paul L,Ornstein

作者单位： Discovery Chemistry Synthesis Group, Centro de Investigación Lilly S.A. Avda. de la Industria , 30 Alcobendas, Madrid 28108, Spain. ^[1] Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States. ^[2] Structural Biology, Eli Lilly and Company, Advanced Photon Source, Argonne National Laboratory, Building 438A, 9700 South Cass Avenue, Argonne, Illinois 60439, United States. ^[3] Neuroscience Research, Eli Lilly and Company , Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, U.K. GU20 6PH. ^[4]