Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.

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作者： Alan Xiangdong,Wang ^[1] ; Jie,Chen ^[2] ; Qian,Zhao ^[2] ; Li-Qiang,Sun ^[2] ; Jacques,Friborg ^[3] ; Fei,Yu ^[3] ; Dennis,Hernandez ^[3] ; Andrew C,Good ^[4] ; Herbert E,Klei ^[4] ; Ramkumar,Rajamani ^[4] ; Kathy,Mosure ^[5] ; Jay O,Knipe ^[5] ; Danshi,Li ^[5] ; Jialong,Zhu ^[5] ; Paul C,Levesque ^[5] ; Fiona,McPhee ^[3] ; Nicholas A,Meanwell ^[2] ; Paul M,Scola ^[2]

作者单位： Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States. Electronic address: alan.wang@bms.com. ^[1] Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States. ^[2] Department of Virology, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States. ^[3] Department of Computational-Aided Drug Design, Bristol-Myers Squibb Research and Development, Research Parkway, Wallingford, CT 06492, United States. ^[4] Global Clinical Research, Bristol-Myers Squibb Research and Development, 5, Research Parkway, Wallingford, CT 06492, United States. ^[5]

关键词 C4 aryl, C4 hydroxy-proline Cardiovascular profiles HCV NS3/4A serine protease inhibitors Potent and orally bioavailable Tripeptide acylsulfonamides