Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats.-论文-万方医学网

作者： Xu-Hua,Ge ^[1] ; Guo-Ji,Zhu ^[2] ; De-Qin,Geng ^[3] ; Han-Zhi,Zhang ^[1] ; Juan-Mei,He ^[1] ; Ai-Zhen,Guo ^[1] ; Lin-Lin,Ma ^[1] ; De-Hua,Yu ^[4]

作者单位： Department of General Medicine, Yangpu Hospital of Tongji University, Department of General Practice of Tongji University, Shanghai 200090, China. ^[1] Department of pediatrics, Soochow University Affiliated Children's Hospital, Soochow University, Suzhou 215003, China. ^[2] Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China. ^[3] Department of General Medicine, Yangpu Hospital of Tongji University, Department of General Practice of Tongji University, Shanghai 200090, China. Electronic address: tongjimge@163.com. ^[4]

主题词动物(Animals);焦虑(Anxiety);细胞凋亡(Apoptosis);脑缺血(Brain Ischemia);CA1区, 海马(CA1 Region, Hippocampal);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);认知障碍(Cognition Disorders);疾病模型, 动物(Disease Models, Animal);酶抑制剂(Enzyme Inhibitors);男(雄)性(Male);迷宫学习(Maze Learning);二甲双胍(Metformin);丝裂原活化蛋白激酶10(Mitogen-Activated Protein Kinase 10);神经保护药(Neuroprotective Agents);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);锥体细胞(Pyramidal Cells);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);再灌注损伤(Reperfusion Injury);信号传导(Signal Transduction)

DOI 10.1016/j.physbeh.2016.12.021

PMID 28017679

发布时间 2022-03-17

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Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats.

Physiology & behavior

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Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats.

Physiology & behavior

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Physiology & behavior

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