Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle.

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作者： Aurélie,Chiche ^[1] ; Isabelle,Le Roux ^[2] ; Mathieu,von Joest ^[1] ; Hiroshi,Sakai ^[3] ; Sabela Búa,Aguín ^[1] ; Coralie,Cazin ^[1] ; Rana,Salam ^[4] ; Laurence,Fiette ^[5] ; Olinda,Alegria ^[1] ; Patricia,Flamant ^[5] ; Shahragim,Tajbakhsh ^[6] ; Han,Li ^[7]

作者单位： Cellular Plasticity & Disease Modelling, Department of Developmental & Stem Cell Biology, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France; CNRS, UMR3738, Rue du Dr Roux, Paris 75015, France. ^[1] Stem Cells & Development, Department of Developmental & Stem Cell Biology, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France. ^[2] Stem Cells & Development, Department of Developmental & Stem Cell Biology, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France; CNRS, UMR3738, Rue du Dr Roux, Paris 75015, France. ^[3] Cellular Plasticity & Disease Modelling, Department of Developmental & Stem Cell Biology, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France. ^[4] Human Histopathology and Animal Models, Department of Infection & Epidemiology, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France. ^[5] Stem Cells & Development, Department of Developmental & Stem Cell Biology, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France; CNRS, UMR3738, Rue du Dr Roux, Paris 75015, France. Electronic address: shahragim.tajbakhsh@pasteur.fr. ^[6] Cellular Plasticity & Disease Modelling, Department of Developmental & Stem Cell Biology, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France; CNRS, UMR3738, Rue du Dr Roux, Paris 75015, France. Electronic address: han.li@pasteur.fr. ^[7]

关键词 IL-6 aging cellular plasticity cellular senescence in?vivo reprogramming pluripotency regeneration skeletal muscle

主题词动物(Animals);小鼠, 近交C57BL(Mice, Inbred C57BL);肌, 骨骼(Muscle, Skeletal);干细胞(Stem Cells)

DOI 10.1016/j.stem.2016.11.020

PMID 28017795

发布时间 2018-03-14

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