A new flavonoid glycoside (APG) isolated from Clematis tangutica attenuates myocardial ischemia/reperfusion injury via activating PKCε signaling.

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作者： Yanrong,Zhu ^[1] ; Shouyin,Di ^[2] ; Wei,Hu ^[3] ; Yingda,Feng ^[4] ; Qing,Zhou ^[5] ; Bing,Gong ^[5] ; Xinlong,Tang ^[5] ; Juntian,Liu ^[6] ; Wei,Zhang ^[6] ; Miaomiao,Xi ^[6] ; Lin,Jiang ^[6] ; Chao,Guo ^[6] ; Jingyi,Cao ^[6] ; Chongxi,Fan ^[3] ; Zhiqiang,Ma ^[7] ; Yang,Yang ^[8] ; Aidong,Wen ^[9]

作者单位： Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, 127, Changle West Road, Xi'an 710032, China; Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, Nanjing 210008, Jiangsu, China. ^[1] Department of Biomedical Engineering, The Fourth Military Medical University, 169, Changle West Road, Xi'an 710032, China; Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1, Xinsi Road, Xi'an 710038, China. ^[2] Department of Biomedical Engineering, The Fourth Military Medical University, 169, Changle West Road, Xi'an 710032, China. ^[3] Institute of Materia Medica, School of Pharmacy, The Fourth Military Medical University, 169, Changle West Road, Xi'an 710032, China. ^[4] Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, Nanjing 210008, Jiangsu, China. ^[5] Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, 127, Changle West Road, Xi'an 710032, China. ^[6] Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1, Xinsi Road, Xi'an 710038, China. ^[7] Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, Nanjing 210008, Jiangsu, China. Electronic address: yang200214yy@163.com. ^[8] Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, 127, Changle West Road, Xi'an 710032, China. Electronic address: aidongwenxijing@163.com. ^[9]

关键词 Apigenin-7-O-β-D-(-6″-p-coumaroyl)-glucopyranoside Hemeoxygenase 1 Mitochondrial oxidative stress Nuclear factor erythroid 2 p45 related factor 2 Protein kinase Cε

主题词动物(Animals);芹菜素(Apigenin);强心药(Cardiotonic Agents);细胞, 培养的(Cells, Cultured);铁线莲属(Clematis);酶激活(Enzyme Activation);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);心肌再灌注损伤(Myocardial Reperfusion Injury);肌细胞, 心脏(Myocytes, Cardiac);氧化性应激(Oxidative Stress);植物提取物(Plant Extracts);蛋白激酶Cε(Protein Kinase C-epsilon);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);信号传导(Signal Transduction)

DOI 10.1016/j.bbadis.2016.12.013

PMID 28024940

发布时间 2018-11-26

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Biochimica et biophysica acta. Molecular basis of disease

2017年1863卷3期

701-711页

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A new flavonoid glycoside (APG) isolated from Clematis tangutica attenuates myocardial ischemia/reperfusion injury via activating PKCε signaling.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

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A new flavonoid glycoside (APG) isolated from Clematis tangutica attenuates myocardial ischemia/reperfusion injury via activating PKCε signaling.

Biochimica et biophysica acta. Molecular basis of disease

相似文献

Biochimica et biophysica acta. Molecular basis of disease

相关期刊

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