The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.-论文-万方医学网

第一作者： Kristian W,Pajtler

第一单位： Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Republic of Korea.;Department of Pediatric Oncology, Hematology and Immunology, University Hospital, Heidelberg, Germany.;German Cancer Consortium (DKTK Core Center Heidelberg), Germany.

作者： Kristian W,Pajtler ^[1] ; Natalie,Sadowski ^[2] ; Sandra,Ackermann ^[3] ; Kristina,Althoff ^[2] ; Kerstin,Schönbeck ^[4] ; Katharina,Batzke ^[2] ; Simon,Schäfers ^[2] ; Andrea,Odersky ^[2] ; Lukas,Heukamp ^[5] ; Kathy,Astrahantseff ^[4] ; Annette,Künkele ^[4] ; Hedwig E,Deubzer ^[4] ; Alexander,Schramm ^[2] ; Annika,Sprüssel ^[6] ; Theresa,Thor ^[7] ; Sven,Lindner ^[2] ; Angelika,Eggert ^[6] ; Matthias,Fischer ^[8] ; Johannes H,Schulte ^[9]

作者单位： Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Republic of Korea.;Department of Pediatric Oncology, Hematology and Immunology, University Hospital, Heidelberg, Germany.;German Cancer Consortium (DKTK Core Center Heidelberg), Germany. ^[1] Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany. ^[2] Department of Pediatric Oncology and Hematology, University Children's Hospital, and Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. ^[3] Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany. ^[4] NEO New Oncology, Cologne, Germany.;Institute for Hematopathology, Hamburg, Germany. ^[5] Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany.;Berlin Institute of Health (BIH), Germany.;German Cancer Consortium (DKTK Berlin), Germany. ^[6] Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany.;German Cancer Consortium (DKTK Essen), Germany.;Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. ^[7] Department of Pediatric Oncology and Hematology, University Children's Hospital, and Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.;Medical Faculty, University of Cologne, Cologne, Germany. ^[8] Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany.;Berlin Institute of Health (BIH), Germany.;German Cancer Consortium (DKTK Berlin), Germany.;German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[9]

医学主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);苯咪唑类(Benzimidazoles);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);剂量效应关系, 药物(Dose-Response Relationship, Drug);女(雌)性(Female);基因剂量(Gene Dosage);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);小鼠, 裸(Mice, Nude);神经母细胞瘤(Neuroblastoma);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质类(Proto-Oncogene Proteins);信号传导(Signal Transduction);噻吩类(Thiophenes);时间因素(Time Factors);肿瘤负荷(Tumor Burden);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.18632/oncotarget.14268

PMID 28036269

发布时间 2023-12-13

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The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.

Oncotarget

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The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.

Oncotarget

相似文献

同项目论文

Oncotarget

相关期刊

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