The determination of 2-(2-hydroxypropanamido) benzoic acid enantiomers and their corresponding prodrugs in rat plasma by UHPLC-MS/MS and application to comparative pharmacokinetic study after a single oral dose.
作者:
主题词
投药, 口服(Administration, Oral);动物(Animals);苯甲酸盐类(Benzoates);色谱法, 高压液相(Chromatography, High Pressure Liquid);药物稳定性(Drug Stability);线性模型(Linear Models);男(雄)性(Male);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);结果可重复性(Reproducibility of Results);敏感性与特异性(Sensitivity and Specificity);立体异构现象(Stereoisomerism);串联质谱法(Tandem Mass Spectrometry)
DOI
10.1016/j.jchromb.2016.11.017
PMID
28040455
发布时间
2017-03-09
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