Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

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作者： Jerome C,Nwachukwu ^[1] ; Sathish,Srinivasan ^[1] ; Nelson E,Bruno ^[1] ; Jason,Nowak ^[1] ; Nicholas J,Wright ^[1] ; Filippo,Minutolo ^[2] ; Erumbi S,Rangarajan ^[1] ; Tina,Izard ^[1] ; Xin-Qui,Yao ^[3] ; Barry J,Grant ^[3] ; Douglas J,Kojetin ^[4] ; Olivier,Elemento ^[5] ; John A,Katzenellenbogen ^[6] ; Kendall W,Nettles ^[7]

作者单位： Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. ^[1] Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. ^[2] Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[3] Department of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. ^[4] Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medical College, 1305 York Avenue, New York, NY 10021, USA. ^[5] Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA. ^[6] Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. Electronic address: knettles@scripps.edu. ^[7]

关键词 X-ray crystallography allosteric signaling breast cancer endocrine disruptor estrogen receptor-α nuclear receptor steroid hormone

主题词抗肿瘤药, 激素(Antineoplastic Agents, Hormonal);乳腺肿瘤(Breast Neoplasms);细胞增殖(Cell Proliferation);结晶学, X线(Crystallography, X-Ray);二聚作用(Dimerization);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);雌激素拮抗剂(Estrogen Antagonists);雌激素受体α(Estrogen Receptor alpha);雌激素类(Estrogens);女(雌)性(Female);人类(Humans);配体(Ligands);模型, 分子(Models, Molecular);蛋白质构象(Protein Conformation);构效关系(Structure-Activity Relationship);肿瘤细胞, 培养的(Tumor Cells, Cultured)

DOI 10.1016/j.chembiol.2016.11.014

PMID 28042045

发布时间 2021-08-16

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Cell chemical biology

2017年24卷1期

35-45页

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Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

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Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

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