Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and laser scanning microscopy.

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作者： Silke B,Lohan ^[1] ; Siavash,Saeidpour ^[2] ; Agnieszka,Solik ^[3] ; Sabine,Schanzer ^[4] ; Heike,Richter ^[4] ; Pin,Dong ^[4] ; Maxim E,Darvin ^[4] ; Roland,Bodmeier ^[3] ; Alexa,Patzelt ^[4] ; Gaith,Zoubari ^[3] ; Michael,Unbehauen ^[5] ; Rainer,Haag ^[5] ; Jürgen,Lademann ^[4] ; Christian,Teutloff ^[2] ; Robert,Bittl ^[2] ; Martina C,Meinke ^[4]

作者单位： Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Charité - Universitätsmedizin Berlin, Germany. Electronic address: silke.lohan@charite.de. ^[1] Freie Universität Berlin, Fachbereich Physik, Berlin, Germany. ^[2] Freie Universität Berlin, Pharmazeutische Technologie, Institut für Pharmazie, Berlin, Germany. ^[3] Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Charité - Universitätsmedizin Berlin, Germany. ^[4] Freie Universität Berlin, Institut für Chemie und Biochemie, Berlin, Germany. ^[5]

关键词 3-(Carboxy)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (PubChem CID: 519874)Confocal Raman microscopy Curcumin (PubChem CID: 969516)Dexamethasone (PubChem CID: 5743)Electron paramagnetic resonance (EPR) spectroscopy Fluorescence microscopy Hydroxy ethyl cellulose (PubChem CID: 24846132)Nanoparticles Propylene glycol monocaprylate (Capryol? 90) (PubChem CID: 53630264)Stearoyl macrogolglycerides (Gelucire? 50/13) (PubChem SID: 135354605)Stratum corneum Topical application Witepsol (ChemIDplus: 0091744422)