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Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure.

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第一作者： Cyril,Le Nouën

第一单位： RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892; lenouenc@niaid.nih.gov Eckard.Wimmer@stonybrook.edu.

作者： Cyril,Le Nouën ^[1] ; Thomas,McCarty ^[2] ; Michael,Brown ^[3] ; Melissa Laird,Smith ^[3] ; Roberto,Lleras ^[3] ; Michael A,Dolan ^[4] ; Masfique,Mehedi ^[2] ; Lijuan,Yang ^[2] ; Cindy,Luongo ^[2] ; Bo,Liang ^[2] ; Shirin,Munir ^[2] ; Joshua M,DiNapoli ^[2] ; Steffen,Mueller ^[5] ; Eckard,Wimmer ^[6] ; Peter L,Collins ^[2] ; Ursula J,Buchholz ^[2]

作者单位： RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892; lenouenc@niaid.nih.gov Eckard.Wimmer@stonybrook.edu. ^[1] RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892. ^[2] Pacific Biosciences Inc., Menlo Park, CA 94025. ^[3] Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892. ^[4] Codagenix Inc., Stony Brook, NY 11790. ^[5] Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 lenouenc@niaid.nih.gov Eckard.Wimmer@stonybrook.edu. ^[6]

关键词 codon pair deoptimization genetic stability live attenuated vaccine negative-strand RNA virus respiratory syncytial virus