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Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis.

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第一作者： Zhong,Xu

第一单位： State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

作者： Zhong,Xu ^[1] ; Yemin,Wang ^[1] ; Keith F,Chater ^[2] ; Hong-Yu,Ou ^[1] ; H Howard,Xu ^[3] ; Zixin,Deng ^[1] ; Meifeng,Tao ^[4]

作者单位： State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. ^[1] Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom. ^[2] Department of Biological Sciences, California State University, Los Angeles, California, USA. ^[3] State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China tao_meifeng@sjtu.edu.cn. ^[4]

关键词 Streptomyces coelicolor antibiotic biosynthesis genome-wide prodiginine transposition mutagenesis