Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.

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作者： Qiuyu Martin,Zhu ^[1] ; Kyung Ae,Ko ^[1] ; Sara,Ture ^[1] ; Michael A,Mastrangelo ^[1] ; Ming-Huei,Chen ^[1] ; Andrew D,Johnson ^[1] ; Christopher J,O'Donnell ^[1] ; Craig N,Morrell ^[1] ; Joseph M,Miano ^[1] ; Charles J,Lowenstein ^[2]

作者单位： From the Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center, NY (Q.M.Z., K.A.K., S.T., M.A.M., C.N.M., J.M.M., C.J.L.); Division of Intramural Research, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, and NHLBI Framingham Heart Study, Framingham, MA (M.-H.C., A.D.J., C.J.O.D.); and Cardiovascular Division, Massachusetts General Hospital, Harvard Medical School, Boston (C.J.O.D.). ^[1] From the Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center, NY (Q.M.Z., K.A.K., S.T., M.A.M., C.N.M., J.M.M., C.J.L.); Division of Intramural Research, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, and NHLBI Framingham Heart Study, Framingham, MA (M.-H.C., A.D.J., C.J.O.D.); and Cardiovascular Division, Massachusetts General Hospital, Harvard Medical School, Boston (C.J.O.D.). charles_lowenstein@urmc.rochester.edu. ^[2]

关键词 gene editing genome-wide association study phenotype thrombosis von Willebrand factor