Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats.-论文-万方医学网

第一作者： Mohammed K,Hankir

第一单位： Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, Universität Leipzig, Liebigstraße 21, 04103 Leipzig, Germany.

作者： Mohammed K,Hankir ^[1] ; Florian,Seyfried ^[2] ; Constantin A,Hintschich ^[1] ; Thi-Ai,Diep ^[3] ; Karen,Kleberg ^[4] ; Mathias,Kranz ^[5] ; Winnie,Deuther-Conrad ^[5] ; Luis A,Tellez ^[6] ; Michael,Rullmann ^[7] ; Marianne,Patt ^[7] ; Jens,Teichert ^[8] ; Swen,Hesse ^[9] ; Osama,Sabri ^[9] ; Peter,Brust ^[5] ; Harald S,Hansen ^[4] ; Ivan E,de Araujo ^[6] ; Ute,Krügel ^[10] ; Wiebke K,Fenske ^[11]

作者单位： Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, Universität Leipzig, Liebigstraße 21, 04103 Leipzig, Germany. ^[1] Department of General and Visceral, Vascular, and Paediatric Surgery, University of Würzburg, 97070 Würzburg, Germany. ^[2] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B Building 18.5, 2200 Copenhagen, Denmark. ^[3] Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, 1165 Copenhagen, Denmark. ^[4] Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318 Leipzig, Germany. ^[5] John B. Pierce Laboratory and Departments of Psychiatry and Physiology, Yale University, New Haven, CT 06519, USA. ^[6] Department of Nuclear Medicine, Universität Leipzig, Liebigstraße 18, 04109 Leipzig, Germany. ^[7] Rudolf Boehm Institute of Pharmacology and Toxicology, Clinical Pharmacology, Universität Leipzig, Härtelstraße 16-18, 04107 Leipzig, Germany. ^[8] Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, Universität Leipzig, Liebigstraße 21, 04103 Leipzig, Germany; Department of Nuclear Medicine, Universität Leipzig, Liebigstraße 18, 04109 Leipzig, Germany. ^[9] Rudolf Boehm Institute of Pharmacology and Toxicology, Universität Leipzig, Härtelstraße 16-18, 04107 Leipzig, Germany. Electronic address: ute.kruegel@medizin.uni-leipzig.de. ^[10] Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, Universität Leipzig, Liebigstraße 21, 04103 Leipzig, Germany. Electronic address: wiebkekristin.fenske@medizin.uni-leipzig.de. ^[11]

主题词投药, 口服(Administration, Oral);动物(Animals);食欲(Appetite);体重(Body Weight);膳食脂肪类(Dietary Fats);多巴胺(Dopamine);内源性大麻酚类(Endocannabinoids);摄食行为(Feeding Behavior);偏食(Food Preferences);胃旁路术(Gastric Bypass);胃肠道(Gastrointestinal Tract);小肠(Intestine, Small);男(雄)性(Male);小鼠, 肥胖(Mice, Obese);模型, 生物学(Models, Biological);新纹状体(Neostriatum);肥胖症(Obesity);油酸类(Oleic Acids);PPARα(PPAR alpha);大鼠, Wistar(Rats, Wistar);受体, 多巴胺D1(Receptors, Dopamine D1);信号传导(Signal Transduction);迷走神经(Vagus Nerve);体重减轻(Weight Loss)

DOI 10.1016/j.cmet.2016.12.006

PMID 28065827

发布时间 2021-11-02

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Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats.

Cell metabolism

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Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats.

Cell metabolism

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Cell metabolism

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