Clinical dose-response for a broad set of biological products: A model-based meta-analysis.

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作者： Joseph,Wu ^[1] ; Anindita,Banerjee ^[2] ; Bo,Jin ^[2] ; Sandeep M,Menon ^[3] ; Steven W,Martin ^[4] ; Anne C,Heatherington ^[2]

作者单位： 1 Biometrics and Data Management, Global Product Development, Groton, CT, USA. ^[1] 2 Early Clinical Development, Worldwide Research & Development, Cambridge, MA, USA. ^[2] 3 Statistical Research Consulting Center, Global Product Development, Cambridge, MA, USA. ^[3] 4 Pharmacometrics, Global Product Development, Cambridge, MA, USA. ^[4]

关键词 Bayesian hierarchical model Emax model Model-based meta-analysis biologics dose–response

主题词算法(Algorithms);贝叶斯定理(Bayes Theorem);生物因子(Biological Factors);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物剂量计算(Drug Dosage Calculations);人类(Humans);模型, 统计学(Models, Statistical)

DOI 10.1177/0962280216684528

PMID 28067121

发布时间 2019-11-08

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