Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence.

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第一作者： Yariv,Mazor

第一单位： Department of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA.

作者： Yariv,Mazor ^[1] ; Kris F,Sachsenmeier ^[2] ; Chunning,Yang ^[1] ; Anna,Hansen ^[3] ; Jessica,Filderman ^[2] ; Kathy,Mulgrew ^[2] ; Herren,Wu ^[1] ; William F,Dall'Acqua ^[1]

作者单位： Department of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA. ^[1] Department of Oncology, MedImmune, Gaithersburg, MD, USA. ^[2] Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD, USA. ^[3]

主题词动物(Animals);抗体, 双特异性(Antibodies, Bispecific);抗体亲和力(Antibody Affinity);抗体特异性(Antibody Specificity);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);小鼠, 裸(Mice, Nude);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1038/srep40098

PMID 28067257

发布时间 2021-01-02

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Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence.

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Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence.

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