Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.-论文-万方医学网

作者： Jorge,Oller ^[1] ; Nerea,Méndez-Barbero ^[1] ; E Josue,Ruiz ^[1] ; Silvia,Villahoz ^[1] ; Marjolijn,Renard ^[2] ; Lizet I,Canelas ^[1] ; Ana M,Briones ^[3] ; Rut,Alberca ^[1] ; Noelia,Lozano-Vidal ^[1] ; María A,Hurlé ^[4] ; Dianna,Milewicz ^[5] ; Arturo,Evangelista ^[6] ; Mercedes,Salaices ^[3] ; J Francisco,Nistal ^[4] ; Luis Jesús,Jiménez-Borreguero ^[7] ; Julie,De Backer ^[3] ; Miguel R,Campanero ^[8] ; Juan Miguel,Redondo ^[1]

作者单位： Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. ^[1] Center for Medical Genetics Ghent, Ghent University Hospital, Ghent, Belgium. ^[2] Department of Pharmacology, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. ^[3] Cardiovascular Surgery and Department of Physiology and Pharmacology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Facultad de Medicina, Universidad de Cantabria, Santander, Spain. ^[4] Division of Medical Genetics, University of Texas, Houston, USA. ^[5] Servei de Cardiologia, Hospital Vall d'Hebron, Barcelona, Spain. ^[6] Centro Nacional de Investigaciones Cardiovasculares and Hospital de la Princesa, Madrid, Spain. ^[7] Department of Cancer Biology, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain. ^[8] Centro de Investigaciones Biomédicas en RED en Enfermedades Cardiovasculares (CIBERCV), Spain. ^[9]

主题词成年人(Adult);老年人(Aged);动物(Animals);主动脉(Aorta);主动脉瘤(Aortic Aneurysm);主动脉瘤, 胸(Aortic Aneurysm, Thoracic);疾病模型, 动物(Disease Models, Animal);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);基因敲低技术(Gene Knockdown Techniques);单倍剂量不足(Haploinsufficiency);人类(Humans);免疫印迹法(Immunoblotting);男(雄)性(Male);马凡综合征(Marfan Syndrome);小鼠(Mice);中年人(Middle Aged);NG-硝基精氨酸甲酯(NG-Nitroarginine Methyl Ester);一氧化氮(Nitric Oxide);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II)

DOI 10.1038/nm.4266

PMID 28067899

发布时间 2022-12-07

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Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.

Nature medicine

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Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.

Nature medicine

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Nature medicine

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