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首页> Science signaling> Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli.

Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli.

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作者： Kirsten R,Guckes ^[1] ; Erin J,Breland ^[2] ; Ellisa W,Zhang ^[1] ; Sarah C,Hanks ^[3] ; Navleen K,Gill ^[4] ; Holly M S,Algood ^[1] ; Jonathan E,Schmitz ^[5] ; Charles W,Stratton ^[6] ; Maria,Hadjifrangiskou ^[1]

作者单位： Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. ^[1] Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. ^[2] Barnard College, New York, NY 10027, USA. ^[3] Vanderbilt University, Nashville, TN 37240, USA. ^[4] Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. ^[5] Veterans Affairs Tennessee Valley Healthcare Services, Nashville, TN 37212, USA. ^[6] Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. maria.hadjifrangiskou@vanderbilt.edu. ^[7] Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA. ^[8]

主题词抗菌药(Anti-Bacterial Agents);细菌蛋白质类(Bacterial Proteins);药物耐受性(Drug Tolerance);大肠杆菌蛋白质类(Escherichia coli Proteins);正铁化合物(Ferric Compounds);基因表达调控, 细菌(Gene Expression Regulation, Bacterial);离子(Ions);多黏菌素B(Polymyxin B);蛋白质结合(Protein Binding);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);转录因子(Transcription Factors);尿路致病性大肠埃希菌(Uropathogenic Escherichia coli)

DOI 10.1126/scisignal.aag1775

PMID 28074004

发布时间 2020-11-23

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Science signaling

Science signaling

2017年10卷461期

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