Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors.

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第一作者： Xinmin S,Li

第一单位： Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

作者： Xinmin S,Li ^[1] ; Slayman,Obeid ^[2] ; Roland,Klingenberg ^[2] ; Baris,Gencer ^[3] ; François,Mach ^[3] ; Lorenz,Räber ^[4] ; Stephan,Windecker ^[4] ; Nicolas,Rodondi ^[5] ; David,Nanchen ^[6] ; Olivier,Muller ^[7] ; Melroy X,Miranda ^[8] ; Christian M,Matter ^[9] ; Yuping,Wu ^[2] ; Lin,Li ^[10] ; Zeneng,Wang ^[1] ; Hassan S,Alamri ^[1] ; Valentin,Gogonea ^[1] ; Yoon-Mi,Chung ^[11] ; W H Wilson,Tang ^[1] ; Stanley L,Hazen ^[11] ; Thomas F,Lüscher ^[1]

作者单位： Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. ^[1] Department of Cardiology, University Heart Center, University Hospital Zurich, Switzerland. ^[2] Department of Cardiology, Cardiovascular Center, University Hospital Geneva, Switzerland. ^[3] Department of Cardiology, Cardiovascular Center, University Hospital Bern, Switzerland. ^[4] Department of General Internal Medicine, University Hospital Bern, Switzerland. ^[5] Institute of Primary Health Care (BIHAM), University of Bern, Switzerland. ^[6] Department of Ambulatory Care and Community Medicine, Lausanne University, Lausanne, Switzerland. ^[7] Department of Cardiology, Cardiovascular Center, University Hospital Lausanne, Switzerland. ^[8] Center for Molecular Cardiology, University of Zurich, Switzerland. ^[9] Department of Mathematics, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA. ^[10] Department of Chemistry, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA. ^[11] Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. ^[12]

关键词 Acute coronary syndrome All-cause mortality Choline Gut microbiota Incident major adverse cardiac events Risk stratification Trimethylamine N-oxide