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Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.

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第一作者： Megan,Lo

第一单位： From the Departments of Protein Chemistry.

作者： Megan,Lo ^[1] ; Hok Seon,Kim ^[2] ; Raymond K,Tong ^[1] ; Travis W,Bainbridge ^[1] ; Jean-Michel,Vernes ^[3] ; Yin,Zhang ^[2] ; Yuwen Linda,Lin ^[4] ; Shan,Chung ^[4] ; Mark S,Dennis ^[2] ; Y Joy Yu,Zuchero ^[5] ; Ryan J,Watts ^[5] ; Jessica A,Couch ^[6] ; Y Gloria,Meng ^[3] ; Jasvinder K,Atwal ^[5] ; Randall J,Brezski ^[2] ; Christoph,Spiess ^[7] ; James A,Ernst ^[8]

作者单位： From the Departments of Protein Chemistry. ^[1] Antibody Engineering. ^[2] Biochemical and Cellular Pharmacology. ^[3] BioAnalytical Sciences. ^[4] Neuroscience, and. ^[5] Neuroscience, and.;Safety Assessment, Genentech Inc., South San Francisco, California 94080. ^[6] Antibody Engineering, spiess.christoph@gene.com. ^[7] From the Departments of Protein Chemistry, ernst.james@gene.com.;Neuroscience, and. ^[8]

关键词 Fc receptor Fc-γ receptor aglycosylation antibody engineering antibody-dependent, cell-mediated cytotoxicity (ADCC)bispecific antibody complement complement-dependent cytotoxicity (CDC)protein stability recombinant protein expression