Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.

导出原文传递

翻译打印收藏纠错

作者： Lukas,Hroch ^[1] ; Patrick,Guest ^[2] ; Ondrej,Benek ^[3] ; Ondrej,Soukup ^[4] ; Jana,Janockova ^[4] ; Rafael,Dolezal ^[5] ; Kamil,Kuca ^[3] ; Laura,Aitken ^[2] ; Terry K,Smith ^[2] ; Frank,Gunn-Moore ^[2] ; Dominykas,Zala ^[2] ; Rona R,Ramsay ^[2] ; Kamil,Musilek ^[6]

作者单位： Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of Pharmaceutical Chemistry and Drug Control, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. ^[1] University of St. Andrews, School of Biology, Medical and Biological Sciences Building or Biomedical Sciences Research Complex, North Haugh, St. Andrews KY16 9ST, United Kingdom. ^[2] University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic. ^[3] University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. ^[4] University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Informatics and Management, Center for Basic and Applied Research, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic. ^[5] University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic. Electronic address: kamil.musilek@gmail.com. ^[6]

关键词 17β-Hydroxysteroid dehydrogenase type 10 (17β-HSD10)Alzheimer's disease (AD)Amyloid-beta peptide (Aβ)Horseradish peroxidase (HRP)Mitochondrial amyloid-binding alcohol dehydrogenase (ABAD)Monoamine oxidase (MAO)