Manganese supplementation increases adiponectin and lowers ICAM-1 and creatinine blood levels in Zucker type 2 diabetic rats, and downregulates ICAM-1 by upregulating adiponectin multimerization protein (DsbA-L) in endothelial cells.
作者:
主题词
3T3-L1细胞(3T3-L1 Cells);脂联素(Adiponectin);动物(Animals);肌酸酐(Creatinine);糖尿病, 实验性(Diabetes Mellitus, Experimental);糖尿病, 2型(Diabetes Mellitus, Type 2);营养保健品(Dietary Supplements);减量调节(Down-Regulation);内皮细胞(Endothelial Cells);基因表达调控(Gene Expression Regulation);谷胱甘肽转移酶(Glutathione Transferase);人类(Humans);胞间黏附分子1(Intercellular Adhesion Molecule-1);男(雄)性(Male);锰(Manganese);小鼠(Mice);氧化性应激(Oxidative Stress);大鼠(Rats);大鼠, Zucker(Rats, Zucker);增量调节(Up-Regulation)
DOI
10.1007/s11010-016-2931-7
PMID
28083716
发布时间
2018-11-13
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