A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma.

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作者： Xiaoyun,Dai ^[1] ; Lingzhi,Wang ^[1] ; Amudha,Deivasigamni ^[2] ; Chung Yeng,Looi ^[3] ; Chandrabose,Karthikeyan ^[4] ; Piyush,Trivedi ^[5] ; Arunachalam,Chinnathambi ^[5] ; Sulaiman Ali,Alharbi ^[6] ; Frank,Arfuso ^[6] ; Arunasalam,Dharmarajan ^[7] ; Boon Cher,Goh ^[7] ; Kam Man,Hui ^[1] ; Alan Prem,Kumar ^[2] ; Mohd Rais,Mustafa ^[8] ; Gautam,Sethi ^[3]

作者单位： Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ^[1] Cancer Science Institute of Singapore, Centre for Translational Medicine, Singapore. ^[2] Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore. ^[3] Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. ^[4] School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India. ^[5] Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia,. ^[6] Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth WA, Australia. ^[7] Department of Haematology-Oncology, National University Health System, Singapore. ^[8] Institute of Molecular and Cell Biology, A*STAR, Biopolis Drive Proteos, Singapore. ^[9] Cancer and Stem Cell Biology Program, Duke-National University of Singapore Graduate Medical School, Singapore. ^[10] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ^[11] Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth WA, Australia. ^[12] Department of Biological Sciences, University of North Texas, Denton, Texas, USA. ^[13] School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth WA, Australia. ^[14]

关键词 HCC JNK MBIC ROS apoptosis