Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.
第一作者:
Mark P,Chao
第一单位:
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, CA 94305, USA; Department of Medicine, Division of Hematology, Stanford Medicine, CA 94305, USA. Electronic address: mpchao@stanford.edu.
作者:
医学主题词
原始细胞危象(Blast Crisis);细胞分化(Cell Differentiation);细胞系, 肿瘤(Cell Line, Tumor);细胞谱系(Cell Lineage);细胞形状(Cell Shape);染色体畸变(Chromosome Aberrations);克隆细胞(Clone Cells);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);基因表达谱(Gene Expression Profiling);基因表达调控, 白血病(Gene Expression Regulation, Leukemic);HEK293细胞(HEK293 Cells);血细胞生成(Hematopoiesis);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);模型, 生物学(Models, Biological);分子靶向治疗(Molecular Targeted Therapy);突变(Mutation);肿瘤侵润(Neoplasm Invasiveness);表型(Phenotype)
DOI
10.1016/j.stem.2016.11.018
PMID
28089908
发布时间
2018-11-13
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Cell stem cell
329-344.e7页
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