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Long-Term Exposure to Imatinib Mesylate Downregulates Hippo Pathway and Activates YAP in a Model of Chronic Myelogenous Leukemia.

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第一作者： Anna,Chorzalska

第一单位： 1 Signal Transduction Laboratory, Division of Hematology/Oncology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University , Providence, Rhode Island.

作者： Anna,Chorzalska ^[1] ; Javier Flores,Kim ^[1] ; Karim,Roder ^[2] ; Alexander,Tepper ^[1] ; Nagib,Ahsan ^[3] ; R Shyama Prasad,Rao ^[4] ; Adam J,Olszewski ^[5] ; Xiaoqing,Yu ^[6] ; Dmitry,Terentyev ^[2] ; John,Morgan ^[7] ; Diana O,Treaba ^[8] ; Ting C,Zhao ^[9] ; Olin,Liang ^[10] ; Philip A,Gruppuso ^[11] ; Patrycja M,Dubielecka ^[1]

作者单位： 1 Signal Transduction Laboratory, Division of Hematology/Oncology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University , Providence, Rhode Island. ^[1] 2 Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School, Brown University , Providence, Rhode Island. ^[2] 3 Division of Biology and Medicine, Brown University , Center for Cancer Research and Development Proteomics Core Facility, Rhode Island Hospital, Providence, Rhode Island. ^[3] 4 Division of Biostatistics and Bioinformatics Division, Yenepoya Research Center, Yenepoya University , Mangalore, India . ^[4] 5 Division of Hematology/Oncology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University , Providence, Rhode Island. ^[5] 6 Department of Biostatistics, Yale School of Public Health , New Haven, Connecticut. ^[6] 7 Flow Cytometry and Cell Sorting Core Facility, Roger Williams Medical Center , Providence, Rhode Island. ^[7] 8 Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University , Providence, Rhode Island. ^[8] 9 Cardiovascular Laboratory, Department of Surgery, Roger Williams Medical Center, Boston University School of Medicine , Providence, Rhode Island. ^[9] 5 Division of Hematology/Oncology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University , Providence, Rhode Island.;10 Department of Orthopedics, Warren Alpert Medical School, Brown University , Providence, Rhode Island. ^[10] 11 Department of Pediatrics, Brown University , Rhode Island Hospital, Providence, Rhode Island. ^[11]

关键词 Hippo pathway YAP chemoresistance imatinib mesylate leukemic stem cells tyrosine kinase inhibitor