Food-grade TiO<sub>2</sub> impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon.-论文-万方医学网

作者： Sarah,Bettini ^[1] ; Elisa,Boutet-Robinet ^[1] ; Christel,Cartier ^[1] ; Christine,Coméra ^[1] ; Eric,Gaultier ^[1] ; Jacques,Dupuy ^[1] ; Nathalie,Naud ^[1] ; Sylviane,Taché ^[1] ; Patrick,Grysan ^[2] ; Solenn,Reguer ^[3] ; Nathalie,Thieriet ^[4] ; Matthieu,Réfrégiers ^[3] ; Dominique,Thiaudière ^[3] ; Jean-Pierre,Cravedi ^[1] ; Marie,Carrière ^[5] ; Jean-Nicolas,Audinot ^[2] ; Fabrice H,Pierre ^[1] ; Laurence,Guzylack-Piriou ^[1] ; Eric,Houdeau ^[1]

作者单位： Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse, France. ^[1] Luxembourg Institute of Science and Technology (LIST), Materials Research and Technology (MRT), Advanced Instrumentation for Ion Nano-Analytics (IANA), L-4362 Esch-sur-Alzette, Luxembourg. ^[2] Synchrotron SOLEIL, F-91192 Gif-sur-Yvette, France. ^[3] French Agency for Food, Environmental and Occupational Health and Safety (ANSES), F-94701 Maisons-Alfort, France. ^[4] Université Grenoble-Alpes, INAC-LCIB, Laboratoire Lésions des Acides Nucléiques, 17 rue des Martyrs, F-38000 Grenoble, France.;CEA, INAC-SCIB, Laboratoire Lésions des Acides Nucléiques, 17 rue des Martyrs, F-38000 Grenoble, France. ^[5]

主题词投药, 口服(Administration, Oral);动物(Animals);细胞计数(Cell Count);细胞分离(Cell Separation);结肠(Colon);细胞因子类(Cytokines);DNA损伤(DNA Damage);树突细胞(Dendritic Cells);上皮细胞(Epithelial Cells);食品(Food);内环境稳定(Homeostasis);免疫系统(Immune System);炎症(Inflammation);肝(Liver);男(雄)性(Male);通透性(Permeability);淋巴集结(Peyer's Patches);癌前状态(Precancerous Conditions);大鼠, Wistar(Rats, Wistar);亚细胞部分(Subcellular Fractions);T淋巴细胞(T-Lymphocytes);组织分布(Tissue Distribution);钛(Titanium)

DOI 10.1038/srep40373

PMID 28106049

发布时间 2025-01-04

检索历史清除

Food-grade TiO<sub>2</sub> impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon.

Scientific reports

相似文献

Scientific reports

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Food-grade TiO<sub>2</sub> impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon.

Scientific reports

相似文献

Scientific reports

相关期刊

检索历史清除