Differential PI3Kδ Signaling in CD4<sup>+</sup> T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy.-论文-万方医学网

第一作者： Shamim,Ahmad

第一单位： Georgia Cancer Center, Augusta University, Augusta, Georgia.

作者： Shamim,Ahmad ^[1] ; Rasha,Abu-Eid ^[2] ; Rajeev,Shrimali ^[3] ; Mason,Webb ^[1] ; Vivek,Verma ^[1] ; Atbin,Doroodchi ^[1] ; Zuzana,Berrong ^[1] ; Raed,Samara ^[4] ; Paulo C,Rodriguez ^[1] ; Mikayel,Mkrtichyan ^[1] ; Samir N,Khleif ^[5]

作者单位： Georgia Cancer Center, Augusta University, Augusta, Georgia. ^[1] Georgia Cancer Center, Augusta University, Augusta, Georgia.;University of Aberdeen Dental School, Foresterhill, Aberdeen, Scotland, United Kingdom. ^[2] Georgia Cancer Center, Augusta University, Augusta, Georgia.;Peloton Therapeutics, Dallas, Texas. ^[3] R&D Project Management Department, Qiagen, Frederick, Maryland. ^[4] Georgia Cancer Center, Augusta University, Augusta, Georgia. skhleif@augusta.edu. ^[5]

医学主题词动物(Animals);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);癌症疫苗(Cancer Vaccines);药物协同作用(Drug Synergism);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);免疫疗法(Immunotherapy);同工酶类(Isoenzymes);淋巴细胞活化(Lymphocyte Activation);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);肿瘤, 实验性(Neoplasms, Experimental);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);嘌呤类(Purines);喹唑啉酮类(Quinazolinones);信号传导(Signal Transduction);T淋巴细胞亚群(T-Lymphocyte Subsets);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory)

DOI 10.1158/0008-5472.CAN-16-1839

PMID 28108509

发布时间 2019-12-10

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Differential PI3Kδ Signaling in CD4<sup>+</sup> T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy.

Cancer research

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Differential PI3Kδ Signaling in CD4<sup>+</sup> T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy.

Cancer research

相似文献

同项目论文

Cancer research

相关期刊

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