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The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

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第一作者： Kenneth D,Bromberg

第一单位： Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.

作者： Kenneth D,Bromberg ^[1] ; Taylor R H,Mitchell ^[2] ; Anup K,Upadhyay ^[1] ; Clarissa G,Jakob ^[1] ; Manisha A,Jhala ^[1] ; Kenneth M,Comess ^[1] ; Loren M,Lasko ^[1] ; Conglei,Li ^[3] ; Creighton T,Tuzon ^[4] ; Yujia,Dai ^[1] ; Fengling,Li ^[2] ; Mohammad S,Eram ^[2] ; Alexander,Nuber ^[5] ; Niru B,Soni ^[1] ; Vlasios,Manaves ^[1] ; Mikkel A,Algire ^[1] ; Ramzi F,Sweis ^[1] ; Maricel,Torrent ^[1] ; Gunnar,Schotta ^[5] ; Chaohong,Sun ^[1] ; Michael R,Michaelides ^[1] ; Alex R,Shoemaker ^[1] ; Cheryl H,Arrowsmith ^[2] ; Peter J,Brown ^[2] ; Vijayaratnam,Santhakumar ^[2] ; Alberto,Martin ^[3] ; Judd C,Rice ^[4] ; Gary G,Chiang ^[6] ; Masoud,Vedadi ^[7] ; Dalia,Barsyte-Lovejoy ^[2] ; William N,Pappano ^[1]

作者单位： Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA. ^[1] Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada. ^[2] Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Canada. ^[3] Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. ^[4] Ludwig-Maximilians-Universität München and Munich Center for Integrated Protein Science (CiPSM), Biomedical Center, Planegg-Martinsried, Germany. ^[5] Discovery, Research and Development, AbbVie, North Chicago, Illinois, USA.;eFFECTOR Therapeutics, San Diego, California, USA. ^[6] Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.;Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. ^[7]