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HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment.

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第一作者： A,Guo

第一单位： Division of Genomic and Molecular Pathology, Department of Pathology, University of Chicago and.

作者： A,Guo ^[1] ; P,Lu ^[1] ; J,Lee ^[1] ; C,Zhen ^[1] ; G,Chiosis ^[2] ; Y L,Wang ^[1]

作者单位： Division of Genomic and Molecular Pathology, Department of Pathology, University of Chicago and. ^[1] Program in Chemical Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ^[2]

医学主题词苯并二恶茂类(Benzodioxoles);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);共同培养技术(Coculture Techniques);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);白血病, 淋巴细胞, 慢性, B细胞(Leukemia, Lymphocytic, Chronic, B-Cell);男(雄)性(Male);线粒体(Mitochondria);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);嘌呤类(Purines);src族激酶类(src-Family Kinases)

DOI 10.1038/onc.2016.494

PMID 28114285

发布时间 2022-04-09

基金项目

R03 MH076499/MH/NIMH NIH HHS/United States UL1 RR024996/RR/NCRR NIH HHS/United States R21 CA158609/CA/NCI NIH HHS/United States P50 CA192937/CA/NCI NIH HHS/United States P30 CA008748/CA/NCI NIH HHS/United States P01 CA186866/CA/NCI NIH HHS/United States TL1 TR000459/TR/NCATS NIH HHS/United States R01 CA172546/CA/NCI NIH HHS/United States

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