An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells.

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第一作者： Jianying,Guo

第一单位： Department of Basic Medical Sciences, School of Medicine, Center for Stem Cell Biology, Tsinghua University, Beijing, 100084, China.

作者： Jianying,Guo ^[1] ; Dacheng,Ma ^[2] ; Rujin,Huang ^[1] ; Jia,Ming ^[1] ; Min,Ye ^[1] ; Kehkooi,Kee ^[1] ; Zhen,Xie ^[2] ; Jie,Na ^[3]

作者单位： Department of Basic Medical Sciences, School of Medicine, Center for Stem Cell Biology, Tsinghua University, Beijing, 100084, China. ^[1] MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, TNLIST/Department of Automation, Tsinghua University, Beijing, 100084, China. ^[2] Department of Basic Medical Sciences, School of Medicine, Center for Stem Cell Biology, Tsinghua University, Beijing, 100084, China. jie.na@tsinghua.edu.cn. ^[3]

关键词 CRISPR NANOG human pluripotent stem cells pluripotency transcription activation

主题词动物(Animals);细胞系(Cell Line);多西环素(Doxycycline);基因表达调控(Gene Expression Regulation);人类(Humans);小鼠(Mice);多潜能干细胞(Pluripotent Stem Cells)

DOI 10.1007/s13238-016-0360-8

PMID 28116670

发布时间 2018-11-13

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