Targeting calcium signaling in cancer therapy.

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作者： Chaochu,Cui ^[1] ; Robert,Merritt ^[2] ; Liwu,Fu ^[3] ; Zui,Pan ^[4]

作者单位： State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; Department of Surgery, Division of Thoracic Surgery, The Ohio State University, Columbus, OH 43210, USA. ^[1] Department of Surgery, Division of Thoracic Surgery, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. ^[2] State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. ^[3] Department of Surgery, Division of Thoracic Surgery, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA. ^[4]

关键词 20-GPPD, 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol Apoptosis CBD, cannabidiol CBG, cannabigerol CPZ, capsazepine CRAC, Ca2+ release-activated Ca2+ channel CTL, cytotoxic T cells CYP3A4, cytochrome P450 3A4 Ca2+ channels CaM, calmodulin CaMKII, calmodulin-dependent protein kinase II Cancer therapy Cell proliferation Channel blockers;ER/SR, endoplasmic/sarcoplasmic reticulum HCX, H+/Ca2+ exchangers IP3, inositol 1,4,5-trisphosphate IP3R (1, 2, 3), IP3 receptor (type 1, type 2, type 3)MCU, mitochondrial Ca2+ uniporter MCUR1, MCU uniporter regulator 1 MICU (1, 2, 3), mitochondrial calcium uptake (type 1, type 2, type 3)MLCK, myosin light-chain kinase Migration NCX, Na+/Ca2+ exchanger NF-κB, nuclear factor-κB NFAT, nuclear factor of activated T cells NSCLC, non-small cell lung cancer OSCC, oral squamous cell carcinoma cells PKC, protein kinase C PM, plasma membrane PMCA, plasma membrane Ca2+-ATPase PTP, permeability transition pore ROS, reactive oxygen species RyR, ryanodine receptor SERCA, SR/ER Ca2+-ATPase SOCE, store-operated Ca2+ entry SPCA, secretory pathway Ca2+-ATPase Store-operated Ca2+ entry TEA, tetraethylammonium TG, thapsigargin TPC2, two-pore channel 2 TRIM, 1-(2-(trifluoromethyl) phenyl) imidazole TRP (A, C, M, ML, N, P, V), transient receptor potential (ankyrin, canonical, melastatin, mucolipin, no mechanoreceptor potential C, polycystic, vanilloid)VGCC, voltage-gated Ca2+ channel mAb, monoclonal antibody

DOI 10.1016/j.apsb.2016.11.001

PMID 28119804

发布时间 2024-06-25

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Acta pharmaceutica Sinica. B

2017年7卷1期

3-17页

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Targeting calcium signaling in cancer therapy.

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Targeting calcium signaling in cancer therapy.

Acta pharmaceutica Sinica. B

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Acta pharmaceutica Sinica. B

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