Transgenic Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-Mediated Viral Gene Targeting for Antiviral Therapy of Bombyx mori Nucleopolyhedrovirus.

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第一作者： Shuqing,Chen

第一单位： Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.;University of Chinese Academy of Sciences, Beijing, China.

作者： Shuqing,Chen ^[1] ; Chengxiang,Hou ^[2] ; Honglun,Bi ^[3] ; Yueqiang,Wang ^[3] ; Jun,Xu ^[1] ; Muwang,Li ^[2] ; Anthony A,James ^[4] ; Yongping,Huang ^[5] ; Anjiang,Tan ^[5]

作者单位： Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.;University of Chinese Academy of Sciences, Beijing, China. ^[1] Sericultural Research Institute, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, China. ^[2] Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. ^[3] Departments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry, University of California, Irvine, Irvine, California, USA. ^[4] Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China yphuang@sibs.ac.cn ajtan01@sibs.ac.cn. ^[5]

关键词 Bombyx mori nucleopolyhedrovirus CRISPR/Cas9 antiviral therapy transgenic silkworm