Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains.

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作者： Susan,Secore ^[1] ; Su,Wang ^[1] ; Julie,Doughtry ^[1] ; Jinfu,Xie ^[1] ; Matt,Miezeiewski ^[2] ; Richard R,Rustandi ^[3] ; Melanie,Horton ^[1] ; Rachel,Xoconostle ^[1] ; Bei,Wang ^[4] ; Catherine,Lancaster ^[3] ; Adam,Kristopeit ^[5] ; Sheng-Ching,Wang ^[5] ; Sianny,Christanti ^[5] ; Salvatore,Vitelli ^[3] ; Marie-Pierre,Gentile ^[5] ; Aaron,Goerke ^[5] ; Julie,Skinner ^[1] ; Erica,Strable ^[4] ; David S,Thiriot ^[4] ; Jean-Luc,Bodmer ^[1] ; Jon H,Heinrichs ^[1]

作者单位： Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America. ^[1] Eurofins Laboratories, Lancaster, Pennsylvania, United States of America. ^[2] Vaccine Analytical Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America. ^[3] Vaccine Drug Product Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America. ^[4] Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America. ^[5]