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Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.

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第一作者： Carmen,Lorenz

第一单位： Max Delbrueck Center for Molecular Medicine (MDC), 13125 Berlin, Germany; Berlin Institute of Health (BIH), Berlin 10117, Germany.

作者： Carmen,Lorenz ^[1] ; Pierre,Lesimple ^[2] ; Raul,Bukowiecki ^[3] ; Annika,Zink ^[4] ; Gizem,Inak ^[3] ; Barbara,Mlody ^[3] ; Manvendra,Singh ^[3] ; Marcus,Semtner ^[3] ; Nancy,Mah ^[5] ; Karine,Auré ^[2] ; Megan,Leong ^[3] ; Oleksandr,Zabiegalov ^[3] ; Ekaterini-Maria,Lyras ^[5] ; Vanessa,Pfiffer ^[3] ; Beatrix,Fauler ^[6] ; Jenny,Eichhorst ^[7] ; Burkhard,Wiesner ^[7] ; Norbert,Huebner ^[3] ; Josef,Priller ^[8] ; Thorsten,Mielke ^[6] ; David,Meierhofer ^[6] ; Zsuzsanna,Izsvák ^[3] ; Jochen C,Meier ^[9] ; Frédéric,Bouillaud ^[2] ; James,Adjaye ^[10] ; Markus,Schuelke ^[5] ; Erich E,Wanker ^[3] ; Anne,Lombès ^[11] ; Alessandro,Prigione ^[12]

作者单位： Max Delbrueck Center for Molecular Medicine (MDC), 13125 Berlin, Germany; Berlin Institute of Health (BIH), Berlin 10117, Germany. ^[1] INSERM U1016, Institut Cochin, Paris 75014, France; CNRS UMR 8104, Paris 75014, France; Université Paris Descartes, Paris 75006, France. ^[2] Max Delbrueck Center for Molecular Medicine (MDC), 13125 Berlin, Germany. ^[3] Max Delbrueck Center for Molecular Medicine (MDC), 13125 Berlin, Germany; Charité - Universitätsmedizin, Berlin 10117, Germany. ^[4] Charité - Universitätsmedizin, Berlin 10117, Germany. ^[5] Max Planck Institute for Molecular Genetics, Berlin 14195, Germany. ^[6] Leibniz Institut für Molekulare Pharmakologie (FMP), Berlin 13125, Germany. ^[7] Berlin Institute of Health (BIH), Berlin 10117, Germany; Charité - Universitätsmedizin, Berlin 10117, Germany; DZNE, Berlin 10117, Germany. ^[8] Max Delbrueck Center for Molecular Medicine (MDC), 13125 Berlin, Germany; Zoological Institute, Braunschweig 38106, Germany. ^[9] Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, Düsseldorf 40225, Germany. ^[10] INSERM U1016, Institut Cochin, Paris 75014, France; CNRS UMR 8104, Paris 75014, France; Université Paris Descartes, Paris 75006, France. Electronic address: anne.lombes@inserm.fr. ^[11] Max Delbrueck Center for Molecular Medicine (MDC), 13125 Berlin, Germany. Electronic address: alessandro.prigione@mdc-berlin.de. ^[12]

关键词 NPCs calcium drug discovery iPSCs induced pluripotent stem cells metabolism mitochondria mitochondrial disorders mtDNA mutations neural progenitors