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Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors.

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第一作者： Huma Aslam,Bhatti

第一单位： H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

作者： Huma Aslam,Bhatti ^[1] ; Memoona,Khatoon ^[1] ; Mariya,Al-Rashida ^[2] ; Huma,Bano ^[1] ; Nafees,Iqbal ^[1] ; Zaib-Un-Nisa ^[3] ; Sammer,Yousuf ^[1] ; Khalid Mohammed,Khan ^[1] ; Abdul,Hameed ^[4] ; Jamshed,Iqbal ^[5]

作者单位： H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. ^[1] Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, Pakistan. ^[2] Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. ^[3] H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: abdul_hameed8@hotmail.com. ^[4] Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: drjamshed@ciit.net.pk. ^[5]

关键词 Alkaline phosphatase inhibitors Ectonucleotidase Intestinal alkaline phosphatase (IAP)Sulfonamides Sultams Tissue non-specific alkaline phosphatase (TNAP)

医学主题词碱性磷酸酶(Alkaline Phosphatase);动物(Animals);牛(Cattle);酶抑制剂(Enzyme Inhibitors);构效关系(Structure-Activity Relationship);磺胺类(Sulfonamides)

DOI 10.1016/j.bioorg.2017.01.008

PMID 28139246

发布时间 2017-12-14

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