In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface.

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作者： Benoît,Bestgen ^[1] ; Zakia,Belaid-Choucair ^[2] ; Thierry,Lomberget ^[3] ; Marc,Le Borgne ^[4] ; Odile,Filhol ^[5] ; Claude,Cochet ^[6]

作者单位： Biology of Cancer and Infection, INSERM, U 1036, 38054 Grenoble, France. benoit.bestgen@gmail.com. ^[1] Biology of Cancer and Infection, University Grenoble-Alpes (UGA), 38000 Grenoble, France. benoit.bestgen@gmail.com. ^[2] Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de Recherche Fondamentale (DRF), Biosciences and Biotechnology Institute of Grenoble (BIG), Biology of Cancer and Infection (BCI), 38054 Grenoble, France. benoit.bestgen@gmail.com. ^[3] Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, 66123 Saarbrücken, Germany. benoit.bestgen@gmail.com. ^[4] Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7 Université Lyon 1, 8 avenue Rockefeller, F-69373 Lyon CEDEX 8, France. benoit.bestgen@gmail.com. ^[5] INSERM U 1163 / CNRS ERL 8254, Institut IMAGINE, Université Paris Descartes, 75015 Paris, France. zbelaidchoucair@gmail.com. ^[6] Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7 Université Lyon 1, 8 avenue Rockefeller, F-69373 Lyon CEDEX 8, France. thierry.lomberget@univ-lyon1.fr. ^[7] Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7 Université Lyon 1, 8 avenue Rockefeller, F-69373 Lyon CEDEX 8, France. marc.le-borgne@univ-lyon1.fr. ^[8] Biology of Cancer and Infection, INSERM, U 1036, 38054 Grenoble, France. odile.filhol-cochet@cea.fr. ^[9] Biology of Cancer and Infection, University Grenoble-Alpes (UGA), 38000 Grenoble, France. odile.filhol-cochet@cea.fr. ^[10] Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de Recherche Fondamentale (DRF), Biosciences and Biotechnology Institute of Grenoble (BIG), Biology of Cancer and Infection (BCI), 38054 Grenoble, France. odile.filhol-cochet@cea.fr. ^[11] Biology of Cancer and Infection, INSERM, U 1036, 38054 Grenoble, France. claude.cochet@cea.fr. ^[12] Biology of Cancer and Infection, University Grenoble-Alpes (UGA), 38000 Grenoble, France. claude.cochet@cea.fr. ^[13] Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de Recherche Fondamentale (DRF), Biosciences and Biotechnology Institute of Grenoble (BIG), Biology of Cancer and Infection (BCI), 38054 Grenoble, France. claude.cochet@cea.fr. ^[14]

关键词 cell death cyclic peptides protein kinase CK2 protein–protein interaction subunit interface

DOI 10.3390/ph10010016

PMID 28165359

发布时间 2020-10-01

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