Structural basis of the specificity of USP18 toward ISG15.-论文-万方医学网

作者： Anja,Basters ^[1] ; Paul P,Geurink ^[2] ; Annika,Röcker ^[1] ; Katharina F,Witting ^[2] ; Roya,Tadayon ^[1] ; Sandra,Hess ^[3] ; Marta S,Semrau ^[1] ; Paola,Storici ^[4] ; Huib,Ovaa ^[4] ; Klaus-Peter,Knobeloch ^[2] ; Günter,Fritz ^[1]

作者单位： Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Breisacherstraße 64, 79106 Freiburg, Germany. ^[1] Department of Chemical Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands. ^[2] Hermann-Staudinger-Graduate school, University of Freiburg, Hebelstrasse 27, 79104 Freiburg, Germany. ^[3] Structural Biology Laboratory, Elettra Sincrotrone Trieste S.C.p.A., SS 14 - km 163,5 in AREA Science Park, 34149 Trieste, Italy. ^[4]

主题词动物(Animals);结晶(Crystallization);结晶学, X线(Crystallography, X-Ray);细胞因子类(Cytokines);内肽酶类(Endopeptidases);HEK293细胞(HEK293 Cells);人类(Humans);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);动力学(Kinetics);模型, 分子(Models, Molecular);突变蛋白质类(Mutant Proteins);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);构效关系(Structure-Activity Relationship);底物特异性(Substrate Specificity);泛素(Ubiquitin);泛素硫酯酶(Ubiquitin Thiolesterase);泛素类(Ubiquitins);斑马鱼(Zebrafish);斑马鱼蛋白质类(Zebrafish Proteins)

DOI 10.1038/nsmb.3371

PMID 28165509

发布时间 2022-01-29

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Structural basis of the specificity of USP18 toward ISG15.

Nature structural & molecular biology

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Nature structural & molecular biology

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Structural basis of the specificity of USP18 toward ISG15.

Nature structural & molecular biology

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Nature structural & molecular biology

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