换一批Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
第一作者：
Louise V,Wain
第一单位：
Department of Health Sciences, University of Leicester, Leicester, UK.;National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
作者：
Louise V,Wain [1]
;
Nick,Shrine [2]
;
María Soler,Artigas [2]
;
A Mesut,Erzurumluoglu [2]
;
Boris,Noyvert [2]
;
Lara,Bossini-Castillo [3]
;
Ma'en,Obeidat [4]
;
Amanda P,Henry [5]
;
Michael A,Portelli [5]
;
Robert J,Hall [5]
;
Charlotte K,Billington [5]
;
Tracy L,Rimington [5]
;
Anthony G,Fenech [6]
;
Catherine,John [2]
;
Tineka,Blake [2]
;
Victoria E,Jackson [2]
;
Richard J,Allen [2]
;
Bram P,Prins [7]
;
Understanding Society Scientific Group [8]
;
Archie,Campbell [8]
;
David J,Porteous [9]
;
Marjo-Riitta,Jarvelin [10]
;
Matthias,Wielscher [11]
;
Alan L,James [12]
;
Jennie,Hui [13]
;
Nicholas J,Wareham [13]
;
Jing Hua,Zhao [14]
;
James F,Wilson [15]
;
Peter K,Joshi [16]
;
Beate,Stubbe [17]
;
Rajesh,Rawal [18]
;
Holger,Schulz [19]
;
Medea,Imboden [19]
;
Nicole M,Probst-Hensch [20]
;
Stefan,Karrasch [17]
;
Christian,Gieger [21]
;
Ian J,Deary [22]
;
Sarah E,Harris [23]
;
Jonathan,Marten [15]
;
Igor,Rudan [24]
;
Stefan,Enroth [24]
;
Ulf,Gyllensten [23]
;
Shona M,Kerr [25]
;
Ozren,Polasek [26]
;
Mika,Kähönen [27]
;
Ida,Surakka [23]
;
Veronique,Vitart [23]
;
Caroline,Hayward [28]
;
Terho,Lehtimäki [29]
;
Olli T,Raitakari [30]
;
David M,Evans [31]
;
A John,Henderson [32]
;
Craig E,Pennell [32]
;
Carol A,Wang [33]
;
Peter D,Sly [34]
;
Emily S,Wan [34]
;
Robert,Busch [34]
;
Brian D,Hobbs [34]
;
Augusto A,Litonjua [35]
;
David W,Sparrow [36]
;
Amund,Gulsvik [36]
;
Per S,Bakke [37]
;
James D,Crapo [38]
;
Terri H,Beaty [39]
;
Nadia N,Hansel [40]
;
Rasika A,Mathias [41]
;
Ingo,Ruczinski [42]
;
Kathleen C,Barnes [43]
;
Yohan,Bossé [44]
;
Philippe,Joubert [45]
;
Maarten,van den Berge [46]
;
Corry-Anke,Brandsma [47]
;
Peter D,Paré [47]
;
Don D,Sin [48]
;
David C,Nickle [49]
;
Ke,Hao [50]
;
Omri,Gottesman [50]
;
Frederick E,Dewey [50]
;
Shannon E,Bruse [51]
;
David J,Carey [51]
;
H Lester,Kirchner [52]
;
Geisinger-Regeneron DiscovEHR Collaboration [52]
;
Stefan,Jonsson [53]
;
Gudmar,Thorleifsson [54]
;
Ingileif,Jonsdottir [53]
;
Thorarinn,Gislason [55]
;
Kari,Stefansson [56]
;
Claudia,Schurmann [56]
;
Girish,Nadkarni [57]
;
Erwin P,Bottinger [58]
;
Ruth J F,Loos [58]
;
Robin G,Walters [59]
;
Zhengming,Chen [58]
;
Iona Y,Millwood [58]
;
Julien,Vaucher [60]
;
Om P,Kurmi [61]
;
Liming,Li [62]
;
Anna L,Hansell [7]
;
Chris,Brightling [34]
;
Eleftheria,Zeggini [34]
;
Michael H,Cho [5]
;
Edwin K,Silverman [3]
;
Ian,Sayers [63]
;
Gosia,Trynka [64]
;
Andrew P,Morris [5]
;
David P,Strachan [1]
;
Ian P,Hall ;
Martin D,Tobin
作者单位：
Department of Health Sciences, University of Leicester, Leicester, UK.;National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
[1]
Department of Health Sciences, University of Leicester, Leicester, UK.
[2]
Wellcome Trust Sanger Institute, Hinxton, UK.
[3]
University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.
[4]
Division of Respiratory Medicine, University of Nottingham, Nottingham, UK.
[5]
Department of Clinical Pharmacology and Therapeutics, University of Malta, Msida, Malta.
[6]
Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
[7]
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.;Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.
[8]
Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.;Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.;Biocenter Oulu, University of Oulu, Oulu, Finland.;Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
[9]
Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
[10]
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.;Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.;School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia.
[11]
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.;School of Population Health, University of Western Australia, Crawley, Western Australia, Australia.;PathWest Laboratory Medicine of Western Australia, Sir Charles Gairdner Hospital, Crawley, Western Australia, Australia.;School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia.
[12]
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
[13]
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.;Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
[14]
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
[15]
Department of Internal Medicine B-Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Greifswald, Germany.
[16]
Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
[17]
Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Neuherberg, Germany.
[18]
Swiss Tropical and Public Health Institute, Basel, Switzerland.;University of Basel, Basel, Switzerland.
[19]
Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
[20]
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.;Department of Psychology, University of Edinburgh, Edinburgh, UK.
[21]
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.;Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
[22]
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
[23]
Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden.
[24]
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.;University of Split School of Medicine, Split, Croatia.
[25]
Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
[26]
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.;National Institute for Health and Welfare (THL), Helsinki, Finland.
[27]
Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, Tampere, Finland.;Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
[28]
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.;Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
[29]
University of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane, Queensland, Australia.;MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
[30]
School of Social and Community Medicine, University of Bristol, Bristol, UK.
[31]
School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
[32]
Child Health Research Centre, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
[33]
Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.;Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
[34]
VA Boston Healthcare System, Boston, Massachusetts, USA.;Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
[35]
Department of Clinical Science, University of Bergen, Bergen, Norway.
[36]
National Jewish Health, Denver, Colorado, USA.;Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colorado, USA.
[37]
Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA.
[38]
Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
[39]
Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
[40]
Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
[41]
Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.
[42]
Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada.;Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec City, Quebec, Canada.
[43]
Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec City, Quebec, Canada.;Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Quebec, Canada.
[44]
University of Groningen, University Medical Center Groningen, Department of Pulmonology, GRIAC Research Institute, Groningen, the Netherlands.
[45]
University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, Groningen, the Netherlands.
[46]
University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.;Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
[47]
Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA.
[48]
Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
[49]
Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA.
[50]
Geisinger Health System, Danville, Pennsylvania, USA.
[51]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
[52]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.;Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
[53]
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.;Department of Respiratory Medicine and Sleep, Landspitali University Hospital Reykjavik, Reykjavik, Iceland.
[54]
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
[55]
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
[56]
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
[57]
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
[58]
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.;Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
[59]
Chinese Academy of Medical Sciences, Beijing, China.;Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China.
[60]
UK Small Area Health Statistics Unit, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.;Imperial College Healthcare NHS Trust, St Mary's Hospital, Paddington, London, UK.
[61]
National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.;Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, UK.
[62]
Department of Biostatistics, University of Liverpool, Liverpool, UK.
[63]
Population Health Research Institute, St George's, University of London, London, UK.
[64]
医学主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);等位基因(Alleles);哮喘(Asthma);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);肺(Lung);男(雄)性(Male);中年人(Middle Aged);多态性, 单核苷酸(Polymorphism, Single Nucleotide);肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);危险因素(Risk Factors)
DOI
10.1038/ng.3787
PMID
28166213
发布时间
2024-05-28
基金项目
MR/N01104X/2/MRC_/Medical Research Council/United Kingdom
R01 HL089856/HL/NHLBI NIH HHS/United States
U01 HL089856/HL/NHLBI NIH HHS/United States
MR/N01104X/1/MRC_/Medical Research Council/United Kingdom
G0902313/MRC_/Medical Research Council/United Kingdom
BB/F019394/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
202849/Z/16/Z/WT_/Wellcome Trust/United Kingdom
MR/P00167X/1/MRC_/Medical Research Council/United Kingdom
MC_U137686851/MRC_/Medical Research Council/United Kingdom
MR/N014995/1/MRC_/Medical Research Council/United Kingdom
R01 HL089897/HL/NHLBI NIH HHS/United States
G0801056/MRC_/Medical Research Council/United Kingdom
MC_QA137853/MRC_/Medical Research Council/United Kingdom
MR/N011317/1/MRC_/Medical Research Council/United Kingdom
U01 HL089897/HL/NHLBI NIH HHS/United States
G1000861/MRC_/Medical Research Council/United Kingdom
MC_UU_12026/2/MRC_/Medical Research Council/United Kingdom
MC_PC_12010/MRC_/Medical Research Council/United Kingdom
MR/K026992/1/MRC_/Medical Research Council/United Kingdom
S10 OD018522/OD/NIH HHS/United States
MR/M022501/1/MRC_/Medical Research Council/United Kingdom
MC_PC_14135/MRC_/Medical Research Council/United Kingdom
MC_PC_15018/MRC_/Medical Research Council/United Kingdom
MC_UU_12013/4/MRC_/Medical Research Council/United Kingdom
CZD/16/6/4/CSO_/Chief Scientist Office/United Kingdom
MC_PC_U127561128/MRC_/Medical Research Council/United Kingdom
G9815508/MRC_/Medical Research Council/United Kingdom
MC_PC_13049/MRC_/Medical Research Council/United Kingdom
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