New Horizons on Molecular Pharmacology Applied to Drug Discovery: When Resonance Overcomes Radioligand Binding.

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第一作者： Larissa,Pernomian

第一单位： Department of Biosciences Applied to Pharmacy, Faculty of Pharmaceutical Sciences from Ribeirao Preto, University of Sao Paulo, P.O. Box: 14040-903, Ribeirao Preto, SP, Brazil.

作者： Larissa,Pernomian ^[1] ; Mayara Santos,Gomes ^[2] ; Josimar Dornelas,Moreira ^[3] ; Carlos Henrique Tomich de Paula,da Silva ^[4] ; Joaquin Maria Campos,Rosa ^[5] ; Cristina Ribeiro de Barros,Cardoso ^[6]

作者单位： Department of Biosciences Applied to Pharmacy, Faculty of Pharmaceutical Sciences from Ribeirao Preto, University of Sao Paulo, P.O. Box: 14040-903, Ribeirao Preto, SP, Brazil. ^[1] Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences from Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil. ^[2] Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. ^[3] Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences from Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil. ^[4] Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, University of Granada, Granada. Spain. ^[5] Department of Biosciences Applied to Pharmacy, Faculty of Pharmaceutical Sciences from Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil. ^[6]

关键词 G protein-coupled receptors (GPCR)NanoLuc luciferase (Nluc)Nluc-based BRET (NanoBRET)bioluminescence resonance energy transfer (BRET)drug discovery ligand binding affinity radioligand binding assay real-time proximity assays