首页> Nature communications> IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP.

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP.

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第一作者： K L,Jønsson

第一单位： Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, Aarhus C 8000, Denmark.;Aarhus Research Centre of Innate Immunology, Aarhus University, Wilhelm Meyers Alle 4, Aarhus C 8000, Denmark.

作者： K L,Jønsson ^[1] ; A,Laustsen ^[1] ; C,Krapp ^[2] ; K A,Skipper ^[1] ; K,Thavachelvam ^[1] ; D,Hotter ^[3] ; J H,Egedal ^[1] ; M,Kjolby ^[4] ; P,Mohammadi ^[5] ; T,Prabakaran ^[1] ; L K,Sørensen ^[6] ; C,Sun ^[1] ; S B,Jensen ^[1] ; C K,Holm ^[1] ; R J,Lebbink ^[7] ; M,Johannsen ^[6] ; M,Nyegaard ^[8] ; J G,Mikkelsen ^[1] ; F,Kirchhoff ^[3] ; S R,Paludan ^[1] ; M R,Jakobsen ^[1]

作者单位： Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, Aarhus C 8000, Denmark.;Aarhus Research Centre of Innate Immunology, Aarhus University, Wilhelm Meyers Alle 4, Aarhus C 8000, Denmark. ^[1] Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, Aarhus C 8000, Denmark.;Ulm University Medical Center, Institute of Molecular Virology, Meyerhofstr. 1, Ulm 89081, Germany. ^[2] Ulm University Medical Center, Institute of Molecular Virology, Meyerhofstr. 1, Ulm 89081, Germany. ^[3] Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, Aarhus C 8000, Denmark.;The Danish Diabetes Academy supported by the Novo Nordisk Foundation, Aarhus University, Nordre Ringgade 1, Aarhus C 8000, Denmark. ^[4] New York Genome Center, 101 Avenue of the Americas, New York City, New York 10013, USA.;Department of Systems Biology, Columbia University, 1130 St Nicholas Avenue, New York City, New York 10032, USA. ^[5] Department of Forensic Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Entrance 1, Aarhus N 8200, Denmark. ^[6] University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, Netherlands. ^[7] Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, Aarhus C 8000, Denmark. ^[8]