Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR/NF-κB and TLR/MAPK signaling in LPS-induced RAW264.7 cells.

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作者： Hua,Li ^[1] ; Jeong-Hyun,Yoon ^[2] ; Hyo-Jun,Won ^[3] ; Hyeon-Seon,Ji ^[4] ; Heong Joo,Yuk ^[2] ; Ki Hun,Park ^[5] ; Ho-Yong,Park ^[6] ; Tae-Sook,Jeong ^[7]

作者单位： Industrial Bio-materials Research Center, KRIBB, Daejeon 34141, Republic of Korea; Department of Biomolecular Science, Korea University of Science and Technology, KRIBB, Daejeon 34141, Republic of Korea. ^[1] Industrial Bio-materials Research Center, KRIBB, Daejeon 34141, Republic of Korea. ^[2] Department of Biomolecular Science, Korea University of Science and Technology, KRIBB, Daejeon 34141, Republic of Korea. ^[3] Industrial Bio-materials Research Center, KRIBB, Daejeon 34141, Republic of Korea; College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea. ^[4] Division of Applied Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. ^[5] Industrial Bio-materials Research Center, KRIBB, Daejeon 34141, Republic of Korea; Insect Biotech Co. Ltd., Daejeon 34054, Republic of Korea. ^[6] Industrial Bio-materials Research Center, KRIBB, Daejeon 34141, Republic of Korea; Department of Biomolecular Science, Korea University of Science and Technology, KRIBB, Daejeon 34141, Republic of Korea. Electronic address: tsjeong@kribb.re.kr. ^[7]

关键词 Anti-inflammation Coumestans Isotrifoliol MAPK Macrophages NF-κB