首页> BMC cancer> First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation.

First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation.

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第一作者： Ramita,Dewan

第一单位： Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

作者： Ramita,Dewan ^[1] ; Alexander,Pemov ^[2] ; Amalia S,Dutra ^[3] ; Evgenia D,Pak ^[3] ; Nancy A,Edwards ^[1] ; Abhik,Ray-Chaudhury ^[1] ; Nancy F,Hansen ^[4] ; Settara C,Chandrasekharappa ^[4] ; James C,Mullikin ^[5] ; Ashok R,Asthagiri ^[6] ; NISC Comparative Sequencing Program ^[1] ; John D,Heiss ^[2] ; Douglas R,Stewart ^[7] ; Anand V,Germanwala

作者单位： Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. ^[1] Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. ^[2] Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. ^[3] Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. ^[4] Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.;NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Rockville, MD, USA. ^[5] Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA. ^[6] Department of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, IL, USA. agermanwala@gmail.com.;Department of Otolaryngology, Edward Hines, Jr. VA Hospital, 2160 South First Avenue, Maywood, IL, 60153, USA. agermanwala@gmail.com. ^[7]

关键词 Case report NF2 gene Single nucleotide polymorphism Somatic mutation Spectral karyotyping Whole exome sequencing