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Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in <i>IDH2</i>- and <i>TET2</i>-Mutant Acute Myeloid Leukemia.

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第一作者: Alan H,Shih
第一单位: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
作者单位: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. [1] Department of Medicine/Hematology-Oncology and Department of Pharmacology, Weill Cornell Medical College, New York, New York.;Department of Physiology and Biophysics and the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York. [2] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. [3] Department of Medicine/Hematology-Oncology and Department of Pharmacology, Weill Cornell Medical College, New York, New York. [4] Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York. [5] Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. [6] Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. [7] Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York. [8] Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.;Department of Medicine/Hematology-Oncology and Department of Pharmacology, Weill Cornell Medical College, New York, New York. [9] Agios Pharmaceuticals, Cambridge, Massachusetts. [10] Department of Physiology and Biophysics and the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York. [11] Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York. [12] Department of Medicine/Hematology-Oncology and Department of Pharmacology, Weill Cornell Medical College, New York, New York. leviner@mskcc.org amm2014@med.cornell.edu. [13] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. leviner@mskcc.org amm2014@med.cornell.edu.;Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.;Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.;Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York. [14]
DOI 10.1158/2159-8290.CD-16-1049
PMID 28193779
发布时间 2026-03-06
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