<i>THADA</i> fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.

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作者： Federica,Panebianco ^[1] ; Lindsey M,Kelly ^[1] ; Pengyuan,Liu ^[2] ; Shan,Zhong ^[1] ; Sanja,Dacic ^[1] ; Xiaosong,Wang ^[1] ; Aatur D,Singhi ^[1] ; Rajiv,Dhir ^[1] ; Simion I,Chiosea ^[1] ; Shih-Fan,Kuan ^[1] ; Rohit,Bhargava ^[1] ; David,Dabbs ^[1] ; Sumita,Trivedi ^[3] ; Manoj,Gandhi ^[4] ; Rachel,Diaz ^[4] ; Abigail I,Wald ^[1] ; Sally E,Carty ^[5] ; Robert L,Ferris ^[3] ; Adrian V,Lee ^[6] ; Marina N,Nikiforova ^[1] ; Yuri E,Nikiforov ^[7]

作者单位： Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. ^[1] Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China. ^[2] Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. ^[3] Affymetrix, Inc., Santa Clara, CA 95051. ^[4] Division of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. ^[5] Department of Pharmacology and Chemical Biology, Women's Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213. ^[6] Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; nikiforovye@upmc.edu. ^[7]

关键词 IGF1R IGF2BP3 chromosomal rearrangements genetics thyroid cancer