G<b>α</b><sub>11</sub> mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

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作者： Caroline M,Gorvin ^[1] ; Fadil M,Hannan ^[1] ; Sarah A,Howles ^[2] ; Valerie N,Babinsky ^[1] ; Sian E,Piret ^[1] ; Angela,Rogers ^[1] ; Andrew J,Freidin ^[1] ; Michelle,Stewart ^[3] ; Anju,Paudyal ^[4] ; Tertius A,Hough ^[4] ; M Andrew,Nesbit ^[4] ; Sara,Wells ^[1] ; Tonia L,Vincent ^[5] ; Stephen Dm,Brown ^[4] ; Roger D,Cox ^[3] ; Rajesh V,Thakker ^[4]

作者单位： Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. ^[1] Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom. ^[2] ARUK Centre for Osteoarthritis Pathogenesis, The Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom. ^[3] Medical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom. ^[4] Biomedical Sciences Research Institute, Ulster University, Coleraine, United Kingdom. ^[5]

主题词动物(Animals);钙(Calcium);疾病模型, 动物(Disease Models, Animal);GTP结合蛋白质α亚单位(GTP-Binding Protein alpha Subunits);HEK293细胞(HEK293 Cells);人类(Humans);高钙尿症(Hypercalciuria);低钙血症(Hypocalcemia);甲状旁腺功能减退症(Hypoparathyroidism);MAP激酶信号系统(MAP Kinase Signaling System);小鼠(Mice);突变(Mutation);萘类(Naphthalenes);甲状旁腺素(Parathyroid Hormone);受体, 钙敏感(Receptors, Calcium-Sensing);受体, G-蛋白偶联(Receptors, G-Protein-Coupled)

DOI 10.1172/jci.insight.91103

PMID 28194447

发布时间 2024-03-06

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G<b>α</b><sub>11</sub> mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

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G<b>α</b><sub>11</sub> mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

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