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Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.

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第一作者： Irina G,Shabalina

第一单位： The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden.

作者： Irina G,Shabalina ^[1] ; Mikhail Yu,Vyssokikh ^[2] ; Natalia,Gibanova ^[1] ; Robert I,Csikasz ^[1] ; Daniel,Edgar ^[3] ; Anne,Hallden-Waldemarson ^[1] ; Zinaida,Rozhdestvenskaya ^[1] ; Lora E,Bakeeva ^[4] ; Valeria B,Vays ^[2] ; Antonina V,Pustovidko ^[2] ; Maxim V,Skulachev ^[5] ; Barbara,Cannon ^[1] ; Vladimir P,Skulachev ^[4] ; Jan,Nedergaard ^[1]

作者单位： The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden. ^[1] The Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russian Federation. ^[2] The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden.;Present address: Buck Institute for research on aging, Novato, CA 94945, USA. ^[3] The Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russian Federation.;Institute of Mitoengineering, Moscow State University, 119992, Moscow, Russian Federation. ^[4] Institute of Mitoengineering, Moscow State University, 119992, Moscow, Russian Federation. ^[5]

关键词 brown adipose tissue cardiolipin longevity mitochondria oxidative stress reactive oxygen species thermogenesis