CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

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第一作者： David H,Spencer

第一单位： Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA.

作者： David H,Spencer ^[1] ; David A,Russler-Germain ^[2] ; Shamika,Ketkar ^[2] ; Nichole M,Helton ^[2] ; Tamara L,Lamprecht ^[3] ; Robert S,Fulton ^[4] ; Catrina C,Fronick ^[4] ; Michelle,O'Laughlin ^[4] ; Sharon E,Heath ^[2] ; Marwan,Shinawi ^[5] ; Peter,Westervelt ^[2] ; Jacqueline E,Payton ^[6] ; Lukas D,Wartman ^[1] ; John S,Welch ^[2] ; Richard K,Wilson ^[4] ; Matthew J,Walter ^[2] ; Daniel C,Link ^[2] ; John F,DiPersio ^[2] ; Timothy J,Ley ^[7]

作者单位： Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA. ^[1] Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. ^[2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[3] The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA. ^[4] Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA. ^[5] Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. ^[6] Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA. Electronic address: timley@wustl.edu. ^[7]

关键词 AML CpG island hypermethylation DNA methylation DNMT3A leukemia