Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial.

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作者： Mahamadou S,Sissoko ^[1] ; Sara A,Healy ^[2] ; Abdoulaye,Katile ^[1] ; Freda,Omaswa ^[3] ; Irfan,Zaidi ^[2] ; Erin E,Gabriel ^[4] ; Bourama,Kamate ^[1] ; Yacouba,Samake ^[1] ; Merepen A,Guindo ^[1] ; Amagana,Dolo ^[1] ; Amadou,Niangaly ^[1] ; Karamoko,Niaré ^[1] ; Amatigue,Zeguime ^[1] ; Kourane,Sissoko ^[1] ; Hama,Diallo ^[1] ; Ismaila,Thera ^[1] ; Kelly,Ding ^[2] ; Michael P,Fay ^[4] ; Elise M,O'Connell ^[5] ; Thomas B,Nutman ^[5] ; Sharon,Wong-Madden ^[2] ; Tooba,Murshedkar ^[3] ; Adam J,Ruben ^[3] ; Minglin,Li ^[3] ; Yonas,Abebe ^[3] ; Anita,Manoj ^[3] ; Anusha,Gunasekera ^[3] ; Sumana,Chakravarty ^[3] ; B Kim Lee,Sim ^[3] ; Peter F,Billingsley ^[3] ; Eric R,James ^[3] ; Michael,Walther ^[2] ; Thomas L,Richie ^[3] ; Stephen L,Hoffman ^[3] ; Ogobara,Doumbo ^[1] ; Patrick E,Duffy ^[6]

作者单位： Malaria Research and Training Center, Mali National Institute of Allergy and Infectious Diseases International Centers for Excellence in Research, University of Science, Techniques and Technologies of Bamako, Bamako, Mali. ^[1] Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[2] Sanaria, Rockville, MD, USA. ^[3] Biostatistical Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[4] Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[5] Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: patrick.duffy@nih.gov. ^[6]