Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.

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第一作者： Xiao,Liu

第一单位： Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.

作者： Xiao,Liu ^[1] ; Tica,Pichulik ^[1] ; Olaf-Oliver,Wolz ^[1] ; Truong-Minh,Dang ^[1] ; Andrea,Stutz ^[2] ; Carly,Dillen ^[3] ; Magno,Delmiro Garcia ^[1] ; Helene,Kraus ^[4] ; Sabine,Dickhöfer ^[1] ; Ellen,Daiber ^[5] ; Lisa,Münzenmayer ^[5] ; Silke,Wahl ^[6] ; Nikolaus,Rieber ^[7] ; Jasmin,Kümmerle-Deschner ^[7] ; Amir,Yazdi ^[8] ; Mirita,Franz-Wachtel ^[6] ; Boris,Macek ^[6] ; Markus,Radsak ^[9] ; Sebastian,Vogel ^[10] ; Berit,Schulte ^[5] ; Juliane Sarah,Walz ^[11] ; Dominik,Hartl ^[7] ; Eicke,Latz ^[12] ; Stephan,Stilgenbauer ^[13] ; Bodo,Grimbacher ^[4] ; Lloyd,Miller ^[3] ; Cornelia,Brunner ^[14] ; Christiane,Wolz ^[5] ; Alexander N R,Weber ^[15]

作者单位： Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany. ^[1] Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany. ^[2] Department of Dermatology, Johns Hopkins University, Baltimore, Md. ^[3] Centre of Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany. ^[4] Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany. ^[5] Proteome Center Tübingen, University of Tübingen, Tübingen, Germany. ^[6] Department of Pediatrics I, University Hospital Tübingen, Tübingen, Germany. ^[7] Department of Dermatology, University Hospital Tübingen, Tübingen, Germany. ^[8] Medical Hospital III, University Hospital Mainz, Mainz, Germany. ^[9] Department of Cardiology and Cardiovascular Diseases, University Hospital Tübingen, Tübingen, Germany. ^[10] Medical Hospital II (Department of Hematology and Oncology), University Hospital Tübingen, Tübingen, Germany. ^[11] Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany; Division of Infectious Diseases & Immunology, University of Massachusetts, Worcester, Mass. ^[12] Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany. ^[13] Department of Otorhinolaryngology, Ulm University Medical Center, Ulm, Germany. ^[14] Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany. Electronic address: alexander.weber@uni.tuebingen.de. ^[15]

关键词 Bruton tyrosine kinase IL-1 Muckle-Wells syndrome NLRP3 Staphylococcus aureus X-linked agammaglobulinemia ibrutinib inflammasome inflammation macrophage